Like others said, of course you can. I've done it a few times and you just need to slow down or your anchor will pull.
Or like Todd said, use sustained anchor casts using your scandi setup if those are the casts you're more consistent with. There's no shame in doing that, in fact I feel a downstream or upstream poke is one of the most powerful casts I can make with my scandi setup and I use them often. There are no hard and fast rules governing which casts you can use with which line system.
"Perhaps fishing is, for me, only an excuse to be near rivers." - Roderick Haig-Brown